基于长余辉体系的长余辉纳米粒子应用进展
首发时间:2020-11-16
摘要:长余辉发光纳米粒子( Persistent Luminescence Nanoparticles,PLNPs)具有诱人的光学性质,在生物医学领域引起了广泛的关注。PLNPs基质材料从最早发现的硫化物基质发展到铝酸盐基质,硅酸盐基质,以及极具发展潜力的镓酸锌(ZGO)基质。ZGO体系的PLNPs具有三维尖晶石结构、大量的反位缺陷、较宽的带隙差、超长的近红外余辉发射,能够消除生物组织的自体荧光干扰,被广泛用于生物检测、诊疗一体化及生物成像等领域。本文介绍了PLNPs的制备方法,评述不同基质PLNPs的性质,讨论了ZGO体系的PLNPs发光性质,总结了ZGO体系的PLNPs在生物检测、成像以及诊疗一体化中的应用,分析了ZGO体系的PLNPs在生物应用中存在的问题及应对策略。
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Advances in the application of Persisitent Luminescence nanoparticles based on zinc-galliate system
Abstract:Persistent luminescence nanoparticles (PLNPs) have attracted much attention in biomedical field due to their attractive optical properties. PLNPs matrix materials have developed from sulfide matrix to aluminate matrix, silicate matrix and zinc galliate (ZGO) matrix with great potential. ZGO matrix have three-dimensional spinel structure,large number of antiposition defects, wide band gap difference and ultra long near-infrared afterglow emission, can eliminate the autofluorescence interference of biological tissues. In this review, the synthetic methods of PLNPs are summarized and their luminescence mechanism is analyzed. The applications of ZGO matrix in biosensing, bioimaging and imaging-guided therapy. The issues and challenges of PLNPs are analyzed for their further prospects.
Keywords: Persistent Lumineces Nanoparticles Biosensing Bioimaging Imaging-guided therapy
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