帕金森病患者的住院指标与季节节律的关系研究
首发时间:2020-12-31
摘要:目的:探究帕金森病帕金森病患者的住院指标与季节节律的关系研究住院患者的指标与季节节律的关系。方法:本文对2015年1月年至2020年10月间就诊于苏州市立医院北区的 182例帕金森病患者入院时间、住院时常、服药剂量等进行回顾性分析。应用圆形统计法分析帕金森病患者入院时间的全年的月份节律性,记录患者的在院时间和服用药物剂量,采用单因素方差分析和Turkey后检验进行分析。结果:帕金森病患者入院时间及其男、女患者组的入院时间均无明显月份节律性(Z=2.87,Z=2.44,Z=1.13;P值均大于0.05)。春、夏、秋、冬每个季节患者的住院时间分别为12.34±2.689天,12.81±1.211天,11.71±0.8248天,12.80±1.548天,单因素方差分析示各组之间无统计学差异。每个季节患者每天的左旋多巴药物剂量分别为465.6±41.72mg,424.8±36.30mg,436.6±28.78mg,441.3±36.66mg,单因素方差分析示各组之间无统计学差异。结论:帕金森病患者的住院指标与季节节律无关,提示帕金森病的严重程度虽然是存在日节律的变化,但周期性的长期季节性波动不明显。
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Study on the relationship between hospitalization indexes and seasonal rhythm in patients with Parkinson\'s disease
Abstract:Objective: To explore the relationship between the indexes of inpatients with Parkinson\'s disease and seasonal rhythm. Methods: from January 2015 to October 2020, 182 patients with Parkinson\'s disease in the North District of Suzhou Municipal Hospital were retrospectively analyzed. The monthly rhythm of admission time of Parkinson\'s disease patients was analyzed by circular statistical method. The time in hospital and drug dosage were recorded. The analysis was conducted by one-way ANOVA and Turkey post test. Results: there was no significant monthly rhythm in the admission time of patients with Parkinson\'s disease (z = 2.87, z = 2.44, z = 1.13; P > 0.05). The hospitalization time of patients in spring, summer, autumn and winter was 12.34 ± 2.689 days, 12.81 ± 1.211 days, 11.71 ± 0.8248 days, 12.80 ± 1.548 days, respectively. The daily doses of levodopa in each season were 465.6 ± 41.72mg, 424.8 ± 36.30mg, 436.6 ± 28.78mg, 441.3 ± 36.66mg, respectively. Conclusion: the hospitalization indexes of patients with Parkinson\'s disease have nothing to do with the seasonal rhythm, which indicates that the severity of Parkinson\'s disease has diurnal rhythm changes, but the periodic long-term seasonal fluctuation is not obvious.
Keywords: Neurology Parkinson\'s Disease seasonal rhythm hospitalization indexes
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