Safety Evaluation of Blueberry Anthocyanin Oral Liquid

• 1、School of Pharmaceutical Science Changchun University of Chinese Medicine
• 2、Department of pharmacy, Bethune first hospital, Jilin University
• 3、The first clinical college of Changchun University of traditional Chinese Medicine

Abstract：Objective to evaluate the safety of blueberry anthocyanin oral liquid. Methods acute toxicity, genetic toxicity and long-term toxicity of blueberry anthocyanin oral liquid were evaluated by acute oral toxicity test, Ames test, micronucleus test of bone marrow polychromatic erythrocytes in mice, sperm deformity test in mice and 30 day feeding test in rats. Results the maximum tolerance dose (MTD) of acute oral test in mice was more than 20 g o (kg o BW) - 1, and the toxicity grade was non-toxic; Compared with the blank group, there was no significant difference in the micronucleus rate of bone marrow polychromatic erythrocytes and the incidence of sperm malformation in each dose group (P > 0.05); the 30 day feeding test showed that there was no significant difference in biochemical indexes, blood indexes and organ indexes between the two groups (P > 0.05). Conclusion blueberry anthocyanin oral liquid has no acute toxicity, genetic toxicity and long-term toxicity within the test dose range, and is safe and non-toxic.

Keywords： blueberry anthocyanin oral liquid genotoxicity safety acute toxicity