中性粒细胞在急性炎症中的性别差异
首发时间:2021-04-16
摘要:目的:研究中性粒细胞在小鼠急性炎症中的性别差异。方法:小鼠腹腔注射酵母多糖,12 h后流式细胞术检测雌雄小鼠腹膜洗液、肠系膜淋巴结、骨髓中中性粒细胞的比例。结果:雌性小鼠腹膜洗液中中性粒细胞的比例明显比雄性小鼠中的高,分别为72.80% ± 8.649%、41.07% ± 8.649%;雌性小鼠肠系膜淋巴结中性粒细胞比例高于雄性小鼠,分别为0.526% ± 0.295%、0.047% ± 0.295%;然而雄性小鼠骨髓中的中性粒细胞比例比雌性小鼠高分别为20.73% ± 3.121%、10.25% ± 3.121%。结论:中性粒细胞在小鼠急性炎症模型中具有性别差异性,炎症高峰期时雌性炎症明显高于雄性。
关键词: 急性炎症、酵母多糖、中性粒细胞、性别差异
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Sex differences of neutrophils in acute inflammation
Abstract:Objective: To study the sex differences of neutrophils in acute inflammation in mice. Methods: Mice were injected intraperitoneally with zymosan. After 12 hours, the proportion of neutrophils in the peritoneal wash, mesenteric lymph nodes and bone marrow of male and female mice was detected by flow cytometry. Results: The percentage of neutrophils in the peritoneal fluid of female mice was significantly higher than that in male mice, which were 72.80% ± 8.649% and 41.07% ± 8.649%, respectively; The proportion of neutrophils in the mesenteric lymph nodes of female mice is higher than that of male mice, which are 0.526% ± 0.295% and 0.047% ± 0.295%; however, the proportion of neutrophils in the bone marrow of male mice is higher than that of female mice, they are 20.73% ± 3.121% and 10.25% ± 3.121% respectively. Conclusion: There have significant sex differences for neutrophils in the acute inflammation model of mice, and the inflammation in females is significantly higher than that in males at the peak of inflammation.
Keywords: Acute inflammation, Zymosan, Neutrophils, Sex differences
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