北五味子功效机制的网络药理学分析
首发时间:2021-04-09
摘要:目的北五味子药用价值较强,且功效作用多样,但目前相关文献主要为其提取物综合功能,具体成分与通路研究较少。本文基于网络药理学收集北五味子所含成分,并对其对应的功效作用进行分析。方法通过中药与化学成分数据库(http://www.organchem.csdb.cn)、PubChem(https://pubchem.ncbi.nlm.nih.gov)和已有文献收集北五味子相关的活性成分,通过Swiss数据库预测北五味子相关靶点。使用String数据库和Cytoscape构建活性成分靶点互作网络以及靶点之间的互作网络进行网络可视化。使用Metascape(https://metascape.org)对关键靶点富集分析,得出靶点通路关系。结果得出北五味子关键靶点,功能相关关键通路,并绘制网络图。结论北五味子中五味子醇、五味子素及戈米辛类成分作用于多靶点、影响多信号通路。其中对关键靶点CXCR2及HDAC1在北五味子抗癌与血压调节方面有一定功效潜力,为生物实验提供功效预测。
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Network pharmacological analysis of the functional of Schisandra
Abstract:Objective The medicinal value of Schisandra chinensis is strong, and its functions are diverse. However, at present, the related literatures mainly focus on the comprehensive functions of its extract, and the specific components and pathways are seldom studied. In this paper, based on network pharmacology, the components contained in Schisandra chinensis were collected, and their corresponding efficacy was analyzed. Methods The active components related to Schisandra chinensis were collected through Chinese Medicine and Chemical Composition Database (http://www.organchem.csdb.cn), Pubchem (https://pubchem.ncbi.nlm.nih.gov) and existing literatures, and the related targets of Schisandra chinensis were predicted through Swiss database. Use String database and Cytoscape to build active ingredient target interaction network and the interaction network between targets for network visualization. Metascape (https://metascape.org) was used for enrichment analysis of key targets to obtain target pathway relationships.Results The key targets and key functional pathways of Schisandra chinensis were obtained, and the network diagram was drawn. Conclusion Schisandrol, schisandroin and gomisin in Schisandrae chinensis act on multiple targets and affect multiple signaling pathways.Among them, the key targets CXCR2 and HDAC1 have certain efficacy potential in anti-cancer and blood pressure regulation of Schisandra chinensis, providing efficacy prediction for biological experiments.
Keywords: Pharmacology Schisandra chinensis Mechanism of efficacy.
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