3D 打印的骨仿生支架的制备及其性能的研究
首发时间:2022-04-20
摘要:仿生骨组织的有机和无机材料,例如甲基丙烯酰化明胶(GelMA)、羟基磷灰石(HAP)和透明质酸(HA)被广泛应用于骨组织工程。本研究基于以上材料,使用 3D 打印技术制备两种不同的骨仿生支架(S-GMH 和 S-GMHH)。体外理化实验结果表明,S-GMH 和 S-GMHH 支架具有连通的孔隙和多孔的特征,良好的热稳定性和流变性能,具有能够促进成骨分化的压缩模量(0.77 MPa-1.26 MPa),以及优异的回弹性能。细胞实验表明,S-GMH 和 S-GMHH 支架的生物相容性好。此外,S-GMHH 支架能够显著促进成骨分化。这项研究提供了两种 3D 打印仿生骨支架,可以成为良好的骨修复植入物。
关键词: 材料学 3D 打印 仿生骨支架 羟基磷灰石 透明质酸
For information in English, please click here
Preparation and properties of 3D printed bone biomimetic scaffolds
Abstract:Organic and inorganic materials with similar composition to bone tissue, such as gelatin methacrylate (GelMA), hydroxyapatite (HAP), and hyaluronic acid (HA), are widely used in bone tissue engineering. In this study, two different bone biomimetic scaffolds (S-GMH and S-GMHH) were fabricated using 3D printing technology based on the above materials. The results of in vitro physicochemical experiments showed that the S-GMH and S-GMHH scaffolds have the characteristics of connected pores and pores, good thermal stability and rheological properties, suitable compressive modulus (0.77 MPa-1.26 MPa) that can promote osteogenic differentiation, and excellent resilience performance. The results of cell experiments showed that S-GMH and S-GMHH scaffolds had good biocompatibility. In addition, the S-GMHH scaffold was able to significantly promote osteogenic differentiation. This study provides twoPreparation and properties of 3Dprinted bone biomimetic scaffolds types of 3D printed biomimetic bone scaffolds that could be good implants for bone repair.
Keywords: Materials 3D printing biomimetic bone scaffolds hydroxyapatite hyaluronic acid
基金:
引用
No.****
动态公开评议
共计0人参与
勘误表
3D 打印的骨仿生支架的制备及其性能的研究
评论
全部评论0/1000