Research on the AP and LM collision based on the rats head integrated injury degree

• 1、College of Pharmacy and Biological Engineering, Chongqing University of Technology, Chongqing, 400054

Abstract：Objective: To explore the relationship between the degree of integrated damage in anterior posterior (anterior posterior, AP) and lateral-medial (lateral-medial, LM) collisions. Methods: 78 male SD rats were randomly divided into control group 0m, experimental group AP 3 groups and LM 3 groups. After adaptive training, the classical Marmarou model was used to construct the mild (0.75m), medium (1.25m), and heavy (1.75m) injury models. The experimental group obtained walking pole experimental data, grasp strength experimental data, and corpus callosum and brainstem cone beam bleeding data before injury and after 24H. The ratios of 4 group of data were combined by factor analysis to quantify the degree of damage. Results: With the AP and LM groups, the peak time and the proportion of bleeding in the corpus callosum and the brainstem. Mathematical fit according to the grade of rat injury model to obtain the relationship between the rank of injury and the value of AP and LM integrated degree of injury. Among them, as the injury grade increases, the difference of the degree of integrated damage value is larger, and the LM group is more severe. Conclusion: There is a mathematical relationship between AP and the degree of integrated damage value of LM . Can provide methods and data support to quantify the degree of brain brain injury and evaluation of head injury criterion provide the basis..

Keywords： biomedical engineering；traumatic brain injury； accelerated injury； animal experiment； factor analysis