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2003-2020 全部
为您找到包含“National Natural Science Foundation”的内容共1515

Ma Shujie,Wang Jianrong,He Jinjiang,Li Bingyan,Zhang Zengli

1,25(OH)2D3 deficiency may be associated with affective disorders, Parkinson's disease, Alzheimer's disease and cognitive abilities. To explore the protective effects of 1,25(OH)2D3 against glutamate-induced damage in a mouse-derived hippocampal HT-22 cells and underlying potential mechanism. The cell survival rate was determined with Cell Counting Kit-8. Cell cycle, apoptosis and reactive oxidative species (ROS) release were detected by FACs technology. Results showed that pretreatment 1,25(OH)2D3 effectively increase HT-22 cell viability up on glutamate exposure. This might be associated with the fact that 1,25(OH)2D3 significantly reduced the percentage of G0/G1 circles (G0/G1%) (p<0.01),increased the proportion of S phase (S%) and G2/M phase (G2/M%) cells (p<0.01). Moreover, apoptosis in HT-22 cells showed the late cell apoptosis rate was decreased (p<0.05) in glutamate group incubated with 1,25(OH)2D3 (i.e. combination group) compared with the glutamate only group. There was an inverse association between the concentration of 1,25(OH)2D3 and apoptosis rate. Meanwhile, the ROS release was elevated in the combination group (p<0.05). Our study indicates that 1,25(OH)2D3 might adversely affect glutamate-induced apoptosis in the HT-22 cells,this might be owing to the fact that 1,25(OH)2D3 could increase cell proliferation and decrease late apoptosis rate. 1,25(OH)2D3 might be a promising therapeutic agent for the treatment of depression.

2017-02-10

National Natural Science Foundation(81372981

Department of Labor Hygiene and Environmental Health, School of Public Health of Soochow University,Suzhou 215123,The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830011,Shanghai Entry-Exit Inspection and Quarantine Bureau Hongkou Office, Shanghai 200135,Department of Nutrition and Food Hygiene, School of Public Health, Soochow Uniiversity, Suzhou 215123,Department of Labor Hygiene and Environmental Health, School of Public Health of Soochow University,Suzhou 215123

#Preventive Medicine and Hygienics#

0评论(0 分享(0)

LI Cheng,LIU Yaobo

Objective: To explore a new model for the study of spinal cord injury, and to prove the possibility of this model. Methods: The Thy1( thymus cell antigen 1, theta)-YFPH transgenic mice and DiI tracing were employed to observe the distribution of corticospinal tract (CST). And lateral spinal cord hemisection injury model was made using the Thy1-YFPH mice. Results: Pyramidal neurons in cerebral cortex layer Ⅴ was specifically labeled and projected to pyramidal decussation in the medulla. In the spinal cord, the YFP labeled projections were distributed at the same locations as dorsal CST (dCST), dorsolateral CST (dlCST) and ventral CST (vCST). YFP positive axons were mostly colocalized with DiI traced dCST both in the spinal cord of uninjured Thy1-YFPH mice. Conclusion: The Thy1-YFPH mice could label the CST in the mouse spinal cord, and could be used as an easy and convenient model to monitor the degeneration, regeneration and remodeling of CST axons after spinal cord injury.

2017-04-11

National Natural Science Foundation(81330026

Institute of Neuroscience,Soochow University,Suzhou 215123,Institute of Neuroscience,Soochow University,Suzhou 215123

#Biology#

0评论(0 分享(0)

ZHANG Junyu,LU Pengfei,LIANG Dan,JIA Baonan

In this paper,Valence Band Anticrossing (VBAC) model is used to investigate band structure of InN1-xBix, GaN1-xBix and AlN1-xBix for the purpose of optimal performance group-III nitride related devices. Obvious reduction in band gap and increase in spin-orbit splitting energy are founded by doping dilute concentration of bismuth in all these III-N material. The band gap of GaN1-xBix and AlN1-xBix show a step change, and this can be explained by the special position relation between of Bi impurity energy level with corresponding host\'s band offsets. We also show how bismuth may be used to form alloys whereby ΔSO>Eg thereby providing a means of suppressing non-radiative CHSH (hot-hole producing) Auger recombination and inter-valence band absorption. For InN1-xBix, bismuth concentration beyond 1.25% is found to be corresponding to the range of ΔSO>Eg and it shows a continuous adjustable bandgap from 0.7 eV to zero. This may make InN1-xBix a potential candidate for near or mid-infrared optoelectronic applications.

2017-11-14

National Natural Science Foundation (61675032

State Key Laboratory of Information Photonics and Optical Communications, Beijing University of Posts and Telecommunications, P.O. Box 72, Beijing 100876, China,State Key Laboratory of Information Photonics and Optical Communications, Beijing University of Posts and Telecommunications, P.O. Box 72, Beijing 100876, China,State Key Laboratory of Information Photonics and Optical Communications, Beijing University of Posts and Telecommunications, P.O. Box 72, Beijing 100876, China,State Key Laboratory of Information Photonics and Optical Communications, Beijing University of Posts and Telecommunications, P.O. Box 72, Beijing 100876, China

#Physics#

0评论(0 分享(0)

YAN Hui,TANG Weihua

GaFeO3 bulks with x from 0.7 to 1.3 have been fabricated by using classic solid-state route. The structural, optical, and magnetic properties have been investigated systematically. The results of EDX demonstrated that the Fe content can be obtained by adjusting the Fe content in the powders. XRD spectra and FULLPROF profile fitting indicated that GFO bulks belong to the orthorhombic structure with space group Pc21n. Phase separation appeared at the Fe content of x=1.3. Meanwhile, the magnetic property measurements suggested that GaFeO3 is ferromagnetic, and magnetic properties can be enhanced by increasing the Fe content, which is of vital importance for the application of ferromagnetic semiconductors.

2017-12-20

National Natural Science Foundation (11404029

School of Science, Beijing University of Posts and Telecommunications, Beijing 100876,School of Science, Beijing University of Posts and Telecommunications, Beijing 100876

#Physics#

0评论(0 分享(0)

Hamad M Semagoto,Kgalalelo Koboyatau,LIU Dasong,Hu Jinhua,LU Naiyan,Liu Xiaoming,Joe M Regenstein,ZHOU Peng

The objective of this study was to investigate the effects of UV induced photo-oxidation on protein modification and corresponding changes in color and solubility of milk protein concentrate powder (MPC70) stored at 25 or 40 C and at 11, 33 or 75% relative humidity (RH), respectively. Protein modifications in the soluble fractions were determined using liquid chromatography-mass spectrometry (LC-MS) and those in insoluble fractions using gel electrophoresis. The results showed that photo-oxidation caused significant decreases in L* value. Moreover, the solubility of photo-oxidized MPC70 decreased significantly, while the MPC70 samples without UV exposure retained their solubility, except at 40 C and 75% RH. For the soluble fractions of photo-oxidized MPC70, the MS spectra showed multiple additional fractions besides the un- and lactosylated intact protein fractions compared to control suggesting that the photo-oxidation induced further modifications of the proteins, which coincided with the formation of carbonyl groups in the protein. The insoluble fractions of photo-oxidized MPC70 were mainly caseins as well as high molecular weight aggregates, resulting mainly from non-disulfide covalent crosslinks induced by photo-oxidation. The results suggested that photo-oxidation could induce modification of protein that eventually contributed to the solubility loss and discoloration of MPC70.?????

2014-04-01

National Natural Science Foundation (No. 31071492

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122,State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122,State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122,State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122,State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122,State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122,Derpartment of Food Science, Cornell University, Ithaca, USA NY14853,State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122

#Food Science and Technology#

0评论(0 分享(0)

LIU Ruiping,WEI Guangmei

In this paper, a generalized negative variable-coefficient eKdV equation is investigated for modeling the oceanic internal solitary wave (ISW). With symbolic computation, Painleve analysis is given out and an auto-Backlund transformation is presented via the truncated Painleve expansion. Meanwhile, two types of expressions for N-soliton-like solution are obtained by Hirota bilinear method. Furthermore, a comparison is made between the solution images and the observed waveform, and the characteristics influenced by the variable coefficients are shown in the present work.

2014-09-12

National Natural Science Foundation (No. 61072145

LIMB and school of mathematics and system sciences,Beihang University, Beijing 100191,LIMB and school of mathematics and system sciences,Beihang University, Beijing 100191

#Mathematics#

1评论(0 分享(0)

Lu Yinglin,Wei Guang-Mei

In this paper, a negative Gardner-KP equation is under investigation, whose Painlev'{e} analysis shows its non-integrability. Via the truncated Painlev'{e} expansion, an auto-B"{a}cklund transformation is presented and analytical solution is given. The bell-polynomial approach is used to obtain N-soliton solution for this non-integrable equation. Moreover, SAR image simulation of internal solitary wave propagation is provided, which shows prospective agreement with the observed SAR image.

2015-10-12

National Natural Science Foundation (No. 61072145

LMIB and School of Mathematics and System Sciences, Beihang University, Beijing 100191,LMIB and School of Mathematics and System Sciences, Beihang University, Beijing 100191

#Mathematics#

0评论(0 分享(0)

GE Jin,GAO Feng,XU Guoyan,SONG Xiaolin

This paper designs an integrated control strategy of vehicle yaw and rollover stability to enhance the active safety of highway vehicles in turning scenario. A rollover predictor is built based on Time-To-Rollover index. Modified Linear Quadratic Regulation is used in roll stability control, and Partial-Integral design is used in yaw stability control. With Carsim and MATLAB, simulations of fishhook maneuver and double lane-change test are conducted to evaluate the effectiveness of the control configuration and to validate the control method. The result shows that this controller performs well in maintaining vehicle roll and yaw stability. This study provides a theoretical basis towards a unified chassis control of coupled roll and yaw stability.

2012-05-21

National Natural Science Foundation (No. 51105021

School of Transportation Science and Engineering, Beihang University, Beijing 100191,School of Transportation Science and Engineering, Beihang University, Beijing 100191,School of Transportation Science and Engineering, Beihang University, Beijing 100191,School of Transportation Science and Engineering, Beihang University, Beijing 100191

#Transportation Engineering#

0评论(0 分享(0)

zhenglong Wang,yuxian Xia

Most fungi have two different conidiation patterns: normal conidiation and microcycle conidiation under different culture conditions, including the nutrients in the medium. However, the mechanism of conidiation pattern shift response to culture conditions is poorly understood. In this study, Metarhizium acridum conducting microcycle conidiation on sucrose yeast extract agar medium (SYA) shifted to normal conidiation when supplemented with sucrose, nitrate, or phosphate. The M. acridum transcripts on SYA, SYA supplemented with sucrose, nitrate or phosphate, and 1/4SDAY were sequenced by Solexa/Illumina deep-sequencing technology. The results showed that 6,931 genes involved in 243 biochemical pathways were either up- or downregulated in response to different nutrients. Comparative analysis demonstrated that 1,859 genes specifically upregulated at the microcycle conidiation stage were selected. One hundred and twelve, 292, or 216 genes might be associated with microcycle conidiation after adding sucrose, nitrate, or phosphates to SYA medium, respectively. Four hundred and seventy genes were specifically upregulated and might be related to normal conidiation. KEGG pathway analysis indicated that these genes were mainly associated with the cell cycle, cell proliferation, metabolism, protein transport and signal transduction, and the mitogen-activated protein kinase signaling and catabolism pathway. Changing sucrose, nitrate or phosphate, led to a shift between microcycle and normal conidiation by perturbing the cell cycle and metabolism of M. acridum. This research provides essential information about the molecular mechanism of conidiation pattern shift induced by single nutrients.

2013-05-01

National Natural Science Foundation(No. 30771446

Genetic Engineering Research Center, College of Life Sciences, Chongqing University, Chongqing 400030,Genetic Engineering Research Center, College of Life Sciences, Chongqing University, Chongqing

#Biology#

0评论(0 分享(0)

LIANG Jinhua,PENG Yuejian

Given a positive integer $n$ and an $r$-uniform hypergraph $F$, the {\em Tur\'an number} $ex(n,F)$ is the maximum number of edges in an $F$-free $r$-uniform hypergraph on $n$ vertices. The {\em Tur\'{a}n density} of $F$ is defined as $\pi(F)=\lim_{n\rightarrow\infty} { ex(n,F) \over {n \choose r } }.$ The {\em Lagrangian density } of $F$ is$\pi_{\lambda}(F)=\sup \{r! \lambda(G):G\;is\;F\text{-}free\}.$ Sidorenko observed that $\pi(F)\le \pi_{\lambda}(F)$, and Pikhurko observed that $\pi(F)=\pi_{\lambda}(F)$ if every pair of vertices in $F$ is contained in an edge of $F$. Recently, Lagrangian densities of hypergraphs and Tur\'{a}n numbers of their extensions have been studied actively. For example, in the paper `A hypergraph Tur\'an theorem via Lagrangians of intersectingfamilies, {\it J. Combin. Theory Ser. A} {\bf 120} (2013), 2020--2038.', Hefetz and Keevash studied the Lagrangian densitiy of the $3$-uniform graph spanned by $\{123, 456\}$ and the Tur\'{a}n number of its extension.In this paper, we show that the Lagrangian density of the $3$-uniform graph spanned by $\{123,234,456\}$ achieves only on $K_5^3$ . Applying it, we get the Tur\'{a}n number of its extension, and show that the unique extremal hypergraph is the balanced complete $5$-partite $3$-uniform hypergraph on $n$ vertices.

2018-05-04

National Natural Science Foundation (11671124

College of Mathematics and Econometrics, Hunan University, Changsha 410082,College of Mathematics and Econometrics, Hunan University, Changsha 410082

#Mathematics#

0评论(0 分享(0)