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2003-2022 全部
为您找到包含“Natural Science Foundation of China”的内容共1576

YUAN Fang,ZHANG Lushun,LI Hongyu,LIAO Miao,LV Meili※,ZHANG Chongjie※

Aims: Growing evidences suggested that angiotensin-converting enzyme (ACE) gene and endothelial nitric oxide synthase (eNOS) gene have been associated with the risk in a wide range of cancers. The objective of this study was to examine whether two DNA polymorphisms at the ACE insertion/deletion (I/D) and NOS intron 4 variable number of tandem repeats (4a/4b) have been linked with the risk of developing hepatocellular carcinoma (HCC) in a Chinese population. Methods: Polymorphisms of ACE I/D and eNOS 4a/4b were genotyped in 293 HCC patients and 384 healthy control subjects using the polymerase chain reaction (PCR). Results: Frequencies of D allele and DD genotype in ACE gene of HCC patients were significantly different from that in healthy controls. However, no differences were observed in eNOS 4a/4b genotype and allele frequencies between the HCC and controls. Conclusions: These findings indicate that the ACE I/D polymorphism may play a role in HCC progression.

2013-01-18

Natural Science Foundation of China (grant no: 81000515

Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China,Department of Pathology, Cheng Du Medical College, Chengdu, 610083, P.R. China,Department of Liver and Vascular Surgery, the West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China,Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, P. R. China,Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China ,Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China

#Basic Medicine#

0评论(0 分享(0)

Wang Tieshan,Ding Jingjie,Cheng Rui,Lu Xia,Zhao Yongtao

The sputtering yields for copper (Cu) and tungsten (W) targets bombarded by Arq+ (1≤q≤16) and Pbq+ (4≤q≤36) ions were measured. The threshold effect was found for the potential sputtering on metals in this work. The sputtering yields remain constant when q<24, however, they grow dramatically with the charge state q when q≥24. For comparison, the sputtering yields on insulator (SiO2) and semiconductor (Si) were also studied. It increases almost linearly with q in Pbq+ impact case. It is considered that the potential sputtering is strongly dependent on the target material properties, especially the conductivity.

2010-12-10

Natural Science Foundation of China(10475035

School of Nuclear Science and Technology, Lanzhou University,School of Nuclear Science and Technology, Lanzhou University,Institute of Morden Physics, Chinese Academy of Science,School of Nuclear Science and Technology, Lanzhou University,Institute of Morden Physics, Chinese Academy of Science

#Physics#

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HUANG Shengnan,LIU Zhiyong,LI Chengyu,YAO Runpeng,LI Danyang,LI Xiang,HOU Li,FENG Hui

In this study, we identified the female-sterile mutant fsm in Chinese cabbage. This mutant, which exhibits stable inheritance, was derived from Chinese cabbage DH line 'FT' using a combination of isolated microspore culture and ethyl methanesulfonate (EMS) mutagenesis. Genetic analysis indicated that the phenotype of fsm is controlled by a single recessive nuclear gene. Morphological observations revealed significant differences between the floral organs of fsm and wild-type line 'FT'. Parts of the pistils of fsm are smaller and shorter than those of 'FT', especially the ovary, which may directly cause the female sterility of the mutant. Comparative transcriptome analysis of 'FT' and fsm using RNA-Seq revealed a total of 1,872 differentially expressed genes (DEGs) between 'FT' and fsm. Of these, a number of genes involved in ovule development were identified, such as PRETTY FEW SEEDS 2 (PFS2) and Temperature-Induced Lipocalin (TIL), which were upregulated in fsm vs. 'FT'. In addition, qRT-PCR analysis of the expression patterns of 18 DEGs confirmed the accuracy of the RNA-seq data. These results shed light on the molecular mechanisms underlying pistil development in Chinese cabbage.

2016-05-23

Natural Science Foundation of China (31272157

Department of Horticulture, Shenyang Agricultural University, 110866,Department of Horticulture, Shenyang Agricultural University, 110866,Department of Horticulture, Shenyang Agricultural University, 110866,Department of Horticulture, Shenyang Agricultural University, 110866,Department of Horticulture, Shenyang Agricultural University, 110866,Department of Horticulture, Shenyang Agricultural University, 110866,Department of Horticulture, Shenyang Agricultural University, 110866,Department of Horticulture, Shenyang Agricultural University, 110866

#Agronomy#

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Zhang Peipei,Zhang Zhongtian,Gui Mengyuan,Wang Taixia

Research was conducted on Rehmannia glutinosa Libosch., a Chinese traditional medicinal plant, to investigate the effects of UV-irradiation and shade on the concentration of catalpol in seedlings and rhizosphere. The plants were grown under three irradiances: full light, partial shade (50% full light), and UV-irradiation. The R. glutinosa seedlings were harvested and the hydroponic culture solution in the containers was collected on day 3, 6, 9, 12, 15 after treatment respectively for determination of catalpol. The results showed that UV-irradiation increased the concentration of catalpol in leaves rapidly at the early stage, and then, instead of increasing, the concentration of catalpol decreased a little. In contrast, the catalpol content in R. glutinosa leaves was reduced under partial shade. Similar trends were observed in roots and stems of R. glutinosa under UV-irradiation and shade. The concentration of catapol in medium in which full-light, shade and UV-irradiated seedlings were grown all increased with time. But the concentration of catapol in medium of UV-irradiated seedlings was greater than that of full-light seedlings, and the concentration of catapol in medium of shade seedlings is lower. Therefore, UV-irradiation increased both production of catalpol in R. glutinosa seedlings, and secretion of catalpol into R. glutinosa rhizosphere. On the contrary shading decreased not only production of catalpol in R. glutinosa seedlings, but also secretion of catalpol into R. glutinosa rhizosphere. It was also found that UV-irradiation decreased the root vigor and partial shading increased the root vigor of R. glutinosa seedlings.

2013-07-02

Natural Science Foundation of China(No.31270225

College of Life Science, Henan Normal University, Xinxiang 453007,College of Life Science,Henan Normal University,453007,Xinxiang,People's Republic of China,College of Life Science,North West University,710069,Xi'an,People's Republic of China,College of Life Science,Henan Normal University,453007,Xinxiang,People's Republic of China

#Biology#

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XU Huanli,LIN Xiukun

Defects in apoptosis are common phenomenon in many types of cancer and are also the critical step in tumorigenesis. Targeting apoptotic pathway has been considered as an intriguing strategy for cancer therapy. Traditional Chinese medicine (TCM) have been used in China for thousands of years, and many of them have been confirmed to be effective in the treatment of different tumors. With an increasing cancer rate worldwide, the anti-tumor effects of TCM attracted more and more attention worldwide. Many TCM have been shown to possess antitumor effects through their multiple actions on multiple targets, and apoptosis pathway related targets are extensively studied and defined to be the most promise targets. This review focuses on several antitumor TCM especially those with clinical efficacy based on their effects on apoptotic signaling pathway. The problem and prospect on TCM development as anticancer agents are also presented.

2014-01-16

Natural Science Foundation of China (no. 81302906)and Specialized Research Fund for the Doctoral Program of Higher Educatio

Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University,Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University

#Basic Medicine#

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Yang Xing,Hu Qian,Lin Xiao,Dinglin Xiaoxiao,Yao Herui

Background:Chemotherapy, being as one of the three cornerstones in breast cancer treatment, is playing an important role in controlling the disease. However, growing evidences indicate that after several regimens, chemotherapy does not effectively alleviate disease for patients with advanced breast cancer. Different studies had indicated that the tumor cells underwent epithelial-mesenchymal transition (EMT). In recent years, there have been literature studies confirmed that miRNAs play a regulatory role in chemotherapy resistance and chemotherapy-induced EMT. However the underlying mechanisms is not clear. Methods:To address this question, we constructed drug-resistant breast cancer cell lines, and then observed if breast cancer resistant cell lines EMT displayed. Changes in cell morphology are observed under the microscope. We also detected the expressions of EMT markers E-cadherin, Vimentin, N-cadherin by qRT-PCR, western blotting, and the invasion and migration ability of tumor cells by modified chamber assay. Results:Compared with the parental cells, there were 16 miRNA expression increased and 20 downregulated miRNA in resistant cell lines, demonstrated by miRNA microarray. Of which miR-200b is the most obvious. Elavated miR-200b level in drug-resistant cells could reverse features of parental cells, and inhibit invasion and migration ability, but increase sensitivity to doxorubicin. Knockdown miR-200b in parental cells can promote transition to mesenchymal features, increase the invasion and migration ability, induce resistance to doxorubicin. Luciferase experiments showed that miR-200b target was FN1.Upregulated miR-200b inhibit FN1 expression and luciferase activity. Compared with the parental cell line, FN1 was significantly elevated in MCF-7/Adr. Knockdowning FN1 reverse mesenchyal features, decrease cell migration and invasion capacity, and improve drug sensitivity to doxorubicin. Conclusion: Our data suggest that FN1 is the target of mir-200b, which gets the regulation role of the chemotherapeutic resistance to doxorubicin in breast cancer cells. Therefore miR-200b may serve as an effective tumor inhibitor, play a role in the future to pave the way for targeted cancer therapy.

2015-10-19

Natural Science Foundation of China (No.81372819)

Department of oncology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University,Department of breast cancer oncology, Foshan Hospital of Sun Yat-Sen University,Department of oncology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University,Department of oncology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University,Department of oncology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

#Clinical Medicine#

0评论(0 分享(0)

Yin Xi,Song Li,Geng Xuhong,Gao Yuan,Wang Jiechao,Li Jianli,Shi Haishui,Hou Yanning

Histone modifications have been implicated in learning and memory. Our previous transcriptome data showed that expression of sirtuins 6 (SIRT6), a member of Histone deacetylases (HDACs) family in the hippocampal cornu ammonis 1 (CA1) was decreased after contextual fear conditioning. However, the role of SIRT6 in the formation of memory is still elusive. In the present study, we found that contextual fear conditioning inhibited translational expression of SIRT6 in the CA1. Microinfusion of lentiviral vector-expressing SIRT6 into the CA1 region selectively enhanced the expression of SIRT6 and impaired the formation of long-term contextual fear memory without affecting short-term fear memory. The overexpression of SIRT6 in the CA1 had no effect on anxiety-like behaviors or locomotor activity. Also, we also found that SIRT6 overexpression significantly inhibited the expression of insulin-like factor 2 (IGF2) and amounts of proteins and/or phosphoproteins (e.g. Akt, pAkt, mTOR and p-mTOR) related to the IGF2 signal pathway in the CA1. These results demonstrate that the overexpression of SIRT6 in the CA1 impaired the formation of long-term fear memory, and SIRT6 in the CA1 may negatively modulate the formation of contextual fear memory via inhibiting the IGF signaling pathway.

2015-10-15

Natural Science Foundation of China (81201038

Department of Functional region of Diagnosis, Hebei Medical University Fourth Hospital, Hebei Medical University, Shijiazhuang, 050011,Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, 050017,Department of Functional region of Diagnosis, Hebei Medical University Fourth Hospital, Hebei Medical University, Shijiazhuang, 050011,Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, 050017,Department of vasculocardiology, Hebei Province Geriatric Hospital, Shijiazhuang, 050011,Department of Pharmacy, the Bethune International Peace Hospital of PLA, Shijiazhuang, 050082,Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, 050017,Department of Pharmacy, the Bethune International Peace Hospital of PLA, Shijiazhuang, 050082

#Biology#

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Zhang Lijun,Buatois Luis M.,MáNGANO Gabriela M.,Qi yongan,Tai Chao

The middle Cambrian Mantou Formation of the Mianchi section of western Henan Province, North China provides an opportunity to address infaunal colonization during the aftermath of the Cambrian explosion. The trace fossil Diplocraterion is common within intertidal very fine-grained sandstone of the Member II of the Mantou Formation (Stage 5). Diplocraterion consists of perpendicular to bedding plane, lined U-shaped burrows with well-developed marginal tubes, having distinctive, dark and light colored, laminae forming retrusive and protrusive spreiten reflecting the activity of a suspension feeder. No scratches are observed on the wall of the marginal tubes. SEM-EDS mapping detection shows that the dark laminae are dominated by Si, Al and Fe, whereas the light laminae are dominated by Ca and Si. Based on ichnological, stratigraphical and SEM-EDS features, it is suggested that the specimens of Diplocraterion studied here results from the equilibrium behavior and that the delayed appearance of this ichnotaxon in North China is due to lack of appropriate siliciclastic facies.

2017-05-05

Natural Science Foundation of China (Nos.41602112

Institute of Resources and Environment, Henan Polytechnic University, Jiaozuo 454003,Department of Geological Sciences, University of Saskatchewan, Saskatoon, Canada S7N 5E2,Department of Geological Sciences, University of Saskatchewan, Saskatoon, Canada S7N 5E2,Institute of Resources and Environment, Henan Polytechnic University, Jiaozuo 454003,Institute of Resources and Environment, Henan Polytechnic University, Jiaozuo 454003

#Earth Science#

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JIANG Haidong,GUO Xiaoqun,BI Kedong

Polythiophene(Pth) is easy to be modified, and holds others unique properties, including that, the degree of polymerization can be controlled, and the nanofibers prepared under special conditions are stronger than aluminum. As a new type of polymer material, polythiophene is the main material for organic semiconductors, electrode materials and sensors. But the mechanical failure of polythiophene materials may lead to the malfunction or even failure of the entire device. However, related researches on the mechanical properties of Pth are mainly concentrated on bulks or films. None of these research has been done on the mechanical properties of single Pth nanofibers. In this thesis, the mechanical properties of Pth nanofibers were experimentally studied and analyzed. For example, the adhesion properties of Pth nanofibers were studied and analyzed. The adhesion between the same probe and Pth nanofibers in the diameter range of 85-180nm was systematically tested by atomic force microscopy. The test results demonstrated that the average adhesion between the Pth nanofibers with the length range of 8-23μm and the AFM probe was 107.02±7.06 nN. After comparing the adhesion test results between the same AFM probes and different nanofibers such as Pth nanofibers, PVDF nanofibers and silver nanowires, it was found that the adhesion between Pth nanofibers and the AFM probe was stronger than that of the others.

2019-05-21

Natural Science Foundation of China (51728501

Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University;School of Mechanical Engineering, Southeast University,The Middle School of Jishui, Jiangxi Province,Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University;School of Mechanical Engineering, Southeast University

#Materials Science#

0评论(0 分享(0)

Lin Ruohong ,Junli Feng,Yuwei Wang,Jianning Liu,Jishuang Chen

The economic importance of tomato is well documented, and tomato has become a model for fleshy fruit development and ripening studies. Plant microRNAs (miRNAs) are small endogenous RNAs that are involved in a variety of activities, including plant development, signal transduction and protein degradation, as well as response to environment stress, and pathogen invasion. Here in this study, we aimed at quantifying the expression alterations of nine miRNAs and target mRNAs in tomato flower and fruit development upon CMV and TAV infections. Three different Cucumber mosaic virus (CMV) strains CMV-Fny, CMV-Fny2b, CMV-Fny-satT1 and Tomato aspermy virus (TAV)-Bj were used in our investigation, and the miRNA/mRNA expression alterations were analyzed by real-time quantitative RT-PCR. The results shown the levels of several miRNA/mRNA pairs were increased upon virus infection. However, the increased levels of individual miRNAs differed for different virus strains, reflecting differences in severity of symptom phenotypes. The altered expression pattern of these miRNA/mRNA pairs and their predicted functions indicate the possible roles in flower and fruit development, and provide experimental data for understanding the miRNA-mediated phenotype alterations in tomato fruit.

2012-01-05

Natural Science Foundation of China ((30971898) and (30800716)

Institute of Bioengineering, Zhejiang Sci-Tech University, HangZhou 310018,Institute of Bioengineering, Zhejiang Sci-Tech University, Hangzhou, 310018,Institute of Bioengineering, Zhejiang Sci-Tech University, Hangzhou, 310018,Institute of Bioengineering, Zhejiang Sci-Tech University, Hangzhou, 310018,Institute of Bioengineering, Zhejiang Sci-Tech University, Hangzhou, 310018

#Biology#

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