您当前所在位置: 首页 > 首发论文
筛选条件

时间

领域

全部

数学(215)

物理学(192)

材料科学(134) 显示更多>>

电子、通信与自动控制技术(125) 化学(122) 计算机科学技术(122) 生物学(96) 临床医学(51) 机械工程(47) 信息科学与系统科学(43) 基础医学(41) 力学(40) 环境科学技术(32) 地球科学(29) 农学(27) 化学工程(26) 土木建筑工程(25) 管理学(22) 药学(20) 能源科学技术(17) 畜牧科学、动物医学(14) 交通运输工程(13) 食品科学技术(13) 预防医学与卫生学(12) 动力与电气工程(10) 经济学(9) 心理学(7) 中医学与中药学(6) 核科学技术(6) 冶金工程技术(4) 天文学(4) 安全科学技术(4) 水产学(4) 矿山工程技术(4) 林学(3) 航空航天科学技术(3) 体育科学(2) 工程与技术科学基础学科(2) 水利工程(2) 图书馆、情报与文献学(1) 教育学(0) 测绘科学技术(0) 纺织科学技术(0)

学术评议

实时热搜榜

我的筛选 >
2003-2020 全部
为您找到包含“Natural Science Foundation of China”的内容共1549

YUAN Fang,ZHANG Lushun,LI Hongyu,LIAO Miao,LV Meili※,ZHANG Chongjie※

Aims: Growing evidences suggested that angiotensin-converting enzyme (ACE) gene and endothelial nitric oxide synthase (eNOS) gene have been associated with the risk in a wide range of cancers. The objective of this study was to examine whether two DNA polymorphisms at the ACE insertion/deletion (I/D) and NOS intron 4 variable number of tandem repeats (4a/4b) have been linked with the risk of developing hepatocellular carcinoma (HCC) in a Chinese population. Methods: Polymorphisms of ACE I/D and eNOS 4a/4b were genotyped in 293 HCC patients and 384 healthy control subjects using the polymerase chain reaction (PCR). Results: Frequencies of D allele and DD genotype in ACE gene of HCC patients were significantly different from that in healthy controls. However, no differences were observed in eNOS 4a/4b genotype and allele frequencies between the HCC and controls. Conclusions: These findings indicate that the ACE I/D polymorphism may play a role in HCC progression.

2013-01-18

Natural Science Foundation of China (grant no: 81000515

Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China,Department of Pathology, Cheng Du Medical College, Chengdu, 610083, P.R. China,Department of Liver and Vascular Surgery, the West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China,Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, P. R. China,Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China ,Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China

#Basic Medicine#

0评论(0 分享(0)

Zhang Peipei,Zhang Zhongtian,Gui Mengyuan,Wang Taixia

Research was conducted on Rehmannia glutinosa Libosch., a Chinese traditional medicinal plant, to investigate the effects of UV-irradiation and shade on the concentration of catalpol in seedlings and rhizosphere. The plants were grown under three irradiances: full light, partial shade (50% full light), and UV-irradiation. The R. glutinosa seedlings were harvested and the hydroponic culture solution in the containers was collected on day 3, 6, 9, 12, 15 after treatment respectively for determination of catalpol. The results showed that UV-irradiation increased the concentration of catalpol in leaves rapidly at the early stage, and then, instead of increasing, the concentration of catalpol decreased a little. In contrast, the catalpol content in R. glutinosa leaves was reduced under partial shade. Similar trends were observed in roots and stems of R. glutinosa under UV-irradiation and shade. The concentration of catapol in medium in which full-light, shade and UV-irradiated seedlings were grown all increased with time. But the concentration of catapol in medium of UV-irradiated seedlings was greater than that of full-light seedlings, and the concentration of catapol in medium of shade seedlings is lower. Therefore, UV-irradiation increased both production of catalpol in R. glutinosa seedlings, and secretion of catalpol into R. glutinosa rhizosphere. On the contrary shading decreased not only production of catalpol in R. glutinosa seedlings, but also secretion of catalpol into R. glutinosa rhizosphere. It was also found that UV-irradiation decreased the root vigor and partial shading increased the root vigor of R. glutinosa seedlings.

2013-07-02

Natural Science Foundation of China(No.31270225

College of Life Science, Henan Normal University, Xinxiang 453007,College of Life Science,Henan Normal University,453007,Xinxiang,People's Republic of China,College of Life Science,North West University,710069,Xi'an,People's Republic of China,College of Life Science,Henan Normal University,453007,Xinxiang,People's Republic of China

#Biology#

0评论(0 分享(0)

Lin Ruohong ,Junli Feng,Yuwei Wang,Jianning Liu,Jishuang Chen

The economic importance of tomato is well documented, and tomato has become a model for fleshy fruit development and ripening studies. Plant microRNAs (miRNAs) are small endogenous RNAs that are involved in a variety of activities, including plant development, signal transduction and protein degradation, as well as response to environment stress, and pathogen invasion. Here in this study, we aimed at quantifying the expression alterations of nine miRNAs and target mRNAs in tomato flower and fruit development upon CMV and TAV infections. Three different Cucumber mosaic virus (CMV) strains CMV-Fny, CMV-Fny2b, CMV-Fny-satT1 and Tomato aspermy virus (TAV)-Bj were used in our investigation, and the miRNA/mRNA expression alterations were analyzed by real-time quantitative RT-PCR. The results shown the levels of several miRNA/mRNA pairs were increased upon virus infection. However, the increased levels of individual miRNAs differed for different virus strains, reflecting differences in severity of symptom phenotypes. The altered expression pattern of these miRNA/mRNA pairs and their predicted functions indicate the possible roles in flower and fruit development, and provide experimental data for understanding the miRNA-mediated phenotype alterations in tomato fruit.

2012-01-05

Natural Science Foundation of China ((30971898) and (30800716)

Institute of Bioengineering, Zhejiang Sci-Tech University, HangZhou 310018,Institute of Bioengineering, Zhejiang Sci-Tech University, Hangzhou, 310018,Institute of Bioengineering, Zhejiang Sci-Tech University, Hangzhou, 310018,Institute of Bioengineering, Zhejiang Sci-Tech University, Hangzhou, 310018,Institute of Bioengineering, Zhejiang Sci-Tech University, Hangzhou, 310018

#Biology#

0评论(0 分享(0)

ZUO Pengjian,CHENG Guangyu,WANG Tao,LI Chunxiao,YIN Geping

Li2FeSiO4/C composite cathode material was prepared by solid-state method with sucrose as carbon source. The effects of carbon content on structure and electrochemical performance of Li2FeSiO4/C cathode materials for lithium-ion batteries were investigated. The materials were characterized comparatively by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), galvanostatic charge-discharge, electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV), respectively. The SEM images showed that the Li2FeSiO4/C consists of partially agglomerated nanoparticles with an average particle size of 100 nm. TEM images confirmed that a carbon layer was formed on the surface of Li2FeSiO4/C particles, which aimed to enhance the electronic conductivity of the material as well as inhibit the agglomeration during annealing process. The electrochemical measurement results revealed that the Li2FeSiO4/C composite with 7.5wt % carbon shows a good electrochemical performance with an initial discharge capacity of 141 mAhog-1 at 0.1C, and remains a discharge capacity of 103.6 mAhog-1 at 0.5C after 50 cycles.

2012-01-11

Natural Science Foundation of China (no. 50902038)

School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China,School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China,School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China,School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China,School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China

#Chemical Engineering#

0评论(0 分享(0)

LU Ling,XU Wei,QIAN Zhehui

Asian options have payoffs that depend strongly on the historical information of the underlying asset price. Although approximated closed formformulas are available with various assumptions, most them do not guarantee the convergence. Thus, binomial tree and PDE methods are two popularnumerical solutions for pricing. However, either the PDE method or binomial tree method has the complexity of $O(N^2)$ at least, where $N$ is thenumber of time steps. This paper proposes a first convergent lattice method with the complexity of $O(N^{1.5})$ based on the willow tree methodcite{Curran01}. The corresponding convergence rate and error bounds are also analyzed. It shows that our proposed method can provide the sameaccuracy as the PDE and binomial tree method, but requires much less computational time. When a quick pricing is required, our method can give the price with precision in a penny less than half second. Finally, numerical results supports our claims.

2014-06-24

Natural Science Foundation of China (11101310

Department of Mathematics, Tongji University, Shanghai,200092,Department of Mathematics, Tongji University, Shanghai,200092,Department of Mathematics, Tongji University, Shanghai,200092

#Mathematics#

0评论(0 分享(0)

Shao Chenxi,He Xiaoxu,Duan Yubing,Bai Fangzhou

Cluster analysis is an important and challenging subject in time series data mining. It has a very important application prospects in many areas, such as medical images, atmosphere, finance, etc. Many current clustering techniques still have many problems, for example, k-means is a very effective method in finding different shapes and tolerating noise, but its result severely depends on the suitable choice of parameters. Inspired by nuclear field in physics, we propose a new dynamic clustering method based on nuclear field and global features for long time series. Basically, each time series is mapped to one data point in global features space, then the data point is considered as a material particle with a spherically symmetric field around it and the interaction of all data points forms a nuclear field. Through the interaction of nuclear force, the initial clusters are iteratively merged and a hierarchy of clusters is generated. Experimental results show that compared with the typical clustering method k-means, the proposed approach enjoys favorite clustering quality and requires no careful parameters tuning.

2014-07-30

Natural Science Foundation of China(NSFC) Gran

College of Computer Science and Technology, USTC,College of Computer Science and Technology, USTC,College of Computer Science and Technology, USTC,College of Computer Science and Technology, USTC

#Computer Science and Technology#

0评论(0 分享(0)

XU Huanli,LIN Xiukun

Defects in apoptosis are common phenomenon in many types of cancer and are also the critical step in tumorigenesis. Targeting apoptotic pathway has been considered as an intriguing strategy for cancer therapy. Traditional Chinese medicine (TCM) have been used in China for thousands of years, and many of them have been confirmed to be effective in the treatment of different tumors. With an increasing cancer rate worldwide, the anti-tumor effects of TCM attracted more and more attention worldwide. Many TCM have been shown to possess antitumor effects through their multiple actions on multiple targets, and apoptosis pathway related targets are extensively studied and defined to be the most promise targets. This review focuses on several antitumor TCM especially those with clinical efficacy based on their effects on apoptotic signaling pathway. The problem and prospect on TCM development as anticancer agents are also presented.

2014-01-16

Natural Science Foundation of China (no. 81302906)and Specialized Research Fund for the Doctoral Program of Higher Educatio

Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University,Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University

#Basic Medicine#

0评论(0 分享(0)

Bao Chongyun,Xiao Yu

Ihe micro-morphology of local micro-environment affects the adhesion, proliferation, differentiation and other acts of cells and microorganisms. To compare the adsorptive behavior of graphite powder and adhesive behavior of microbe on micro-structures, we prepared micro-structures on hydroxyapatite (HA) with different sizes and shapes. The results showed that Candida albicans was mostly prone to adhere onto 5 μm micro-structures, while 10-20 μm graphite powder was mostly prone onto adsorb to 10 μm and 20 μm micro-structures. The adhesion of Streptococcus mutans which grew in a chain was almost not affected by the size or shape of micro-structures, however, its proliferation was obstructed by micro-structures.

2014-03-13

Natural Science Foundation of China (No. 81371181

State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu ,610041,State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu ,610041

#Basic Medicine#

0评论(0 分享(0)

Bao Chongyun,Xiao Yu

Surface microstructure of implant materials is an essential factor to determine the adhesion and proliferation behaviors of cells and bacteria. However, it is still unclear which kind of morphological characteristics plays dominant roles. For this purpose, hydroxyapatite (HA) and polydimethylsiloxane (PDMS) chips were prepared firstly with different types of microstructures and the C2C12 cells were seeded on these chips to investigate which microstructures could affect the behavior of cells. Next, Staphylococcus aureus(S.a) and Porphyromonas gingivalis(P.g) were cultured on the PDMS matrix, respectively, to analyze the performance of bacteria on varied surface microstructures. The results illustrated much more C2C12 cells seeded on the HA chips than the PDMS replicas, indicating HA are more suitable for the cell's culture. Moreover, further observation and comparison represented both HA and PDMS samples illustrated a similar trend that the cells mainly adhered and proliferated on the submicron structure region rather than microstructure region. By contrast, the bacteria were significantly preferable to the microstructure regions. Overall, on account of different performance of cells and bacteria, we drew the conclusion that the surface roughness (RA) of implant materials should be manufactured in submicron-scale rather than micro-scale for improving the biocompatibility of biomaterials.

2014-03-13

Natural Science Foundation of China (No. 81371181

State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041,State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041

#Basic Medicine#

0评论(0 分享(0)

WANG Zheng,XIA Yuan,JI Xiang

Studies of lizards and snakes have shown that an experimental reduction of offspring number sometimes, but not always, results in an increase in offspring size. We applied the "follicle ablation" technique to an oviparous lacertid lizard (Eremias argus) to test the hypothesis that offspring size can be easily altered by manipulating clutch size in species with a low clutch frequency. Our manipulation of clutch size had the effect of inducing variation in egg size in the first post-surgical clutch, with follicle-ablated females producing fewer larger eggs than did controls. Follicle-ablated females produced a second post-surgical clutch as normally as did controls. The proportional amount of resources allocated to reproduction did not shift seasonally in E. argus, but females normally switched from producing a larger number of smaller eggs early in the breeding season to a smaller number of larger eggs later in the season. Females used in this study never produce more than two clutches per breeding season. Therefore, our data validate the hypothesis tested. Our data also provide an inference that maximization of reproductive success could be achieved in females of E. argus by diverting a larger enough, rather than an extraordinarily high, fraction of the available energy to individual offspring in single reproductive episodes.?????

2011-02-21

Natural Science Foundation of China (30770378)

College of Life Science, Nanjing Normal University,College of Life and Environmental Sciences, Hangzhou Normal University,College of Life Science, Nanjing Normal University

#Biology#

0评论(0 分享(0)