Alzheimer's disease (AD) is a progressive neurodegenerative disorder and one of the most common causes of dementia in the elderly. Acetylcholine esterase inhibitors (AChEI) are the main drugs used in the treatment of AD. In this work, docking studies have been performed in order to understand the in-teraction between a number of inhibitors (tacrine, rivastigmine, huperzine A, TV-3326 (ladostigil), donepezil and anseculin) and acetylcholine esterase (AChE). The calculated binding affinities between inhibitors and AChE increase in the order tacrine<rivastigmine<huperzine A<TV?3326 <donepezil<anseculin, which reflects the experimental inhibitory activity expressed in terms of the half maximal inhibitory concentration (the IC50 value). Of the above inhibitors, anseculin is the most useful drug for the treatment of dementia.