In this paper, a frame of natural computation has been proposed in order to deal with the challenge from new computing braches such as DNA computation and quantum computation to traditional computing theory, and computation is considered as the inherent mechanism of the nature and the foundation of intelligence. Simulating computation has been created and improved viainspiration of natural computation, and Artificial Intelligence has been stablished on simulation of human brain computing pattern. According to this view, generalized mapping from computing panem existing in the nature to current burgeoning new computing panem inspired by the nature has been modeled, and then a coding and control mechanism of natural CO putation bas been analyzed with formalizing tools. So it can be concluded the theow foundation, intelligent power, and application hme will improve the sciences, such as computer science, artificial intelligence etc.