Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus，成果详细信息-中国科技论文在线

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Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus

，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，，曹志伟 Consortium for Influenza Study at Shanghai (WU Di XU TianLei SUN Jing DAI JianXin DING GuoHui HE YunGang ZHOU ZhengFeng XIONG Hui DONG Hui JIN WeiRong BIAN Chao JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang WANG Hao CHE XiaoYan HUANG Zhong LAN Ke SUN Bing WU Fan YUAN ZhenAn ZHANG Xi ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi GUO YaJun ZHAO GuoPing † LI YiXue † & CAO ZhiWei †)

Consortium for Influenza Study at Shanghai. Chinese Science Bulletin | July 2009 | vol. 54 | no. 13，-0001，（）：

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摘要/描述

In recent months, a novel influenza virus H1N1 broke out around the world. With bioinformatics technology, the 3D structure of HA protein was obtained, and the epitope residues were predicted with the method developed in our group for this novel flu virus. 58 amino acids were identified as potential epitope residues, the majority of which clustered at the surface of the globular head of HA protein. Although it is located at the similar position, the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses.

关键词: novel H1N1 influenza virus, ， HA protein, ， spatial epitope, ， bioinformatics

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