This paper presents a new control approach which can restrain the vibration of centrifuges. In the new scheme, changed support stiffness and self-tuning feed-forward PID control of the decreased vibration force are effectively combined. Some advanced techniques, (such as adaptive modification for unstable vibration regions, two-livel computer control, curve-traching control), are used to make the centrifuge system run in a minimum-vibration state. A horizontal centrifugal experiment is used to test the new control method. Experimental results show the effectiveness of the proposed scheme.