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期刊论文
Cytotoxic Isoprenylated Flavonoids from the Roots of Sophora flavescens
HELVETICA CHIMICA ACTA-Vol. 87(2004),-0001,():
Three new flavonoids, which are isoprenylated by fused 2,2-dimethyl-3,4-dihydro-2H-pyran moieties, were isolated from the roots of Sophora flavescens and named flavenochromanes A-C (1-3). Their structures were elucidated by spectroscopic methods, including 2D-NMRtechniq ues. Flavenochromane C (3) showed strong cytotoxic activity against A549 (lung carcinoma), 1A9 (ovarian carcinoma), KB (epidermoid carcinoma of the nasopharynx), and KB-Vin (drug-resistant variant KB) cell lines with IC50 values ≤1.7µM, and significant activity against the MCF-7 (breast adenocarcinoma) cell line with an IC50 value of 3.6µM Flavenochromane B (2) displayed slightly lower inhibitory effects (IC50 3.2-6.9µM) as compared with 3.
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