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陈晓光

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Intravenous Bone Marrow Stromal Cell Therapy Reduces Apoptosis and Promotes Endogenous Cell Proliferation After Stroke in Female Rat

陈晓光Jieli Chen Yi Li Mark Katakowski Xiaoguang Chen Lei Wang Dunyue Lu Mei Lu Subhash C. Gautam and Michael Chopp*

Journal of Neuroscience Research 2003, 73, 778-786,-0001,():

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摘要/描述

The present study investigates the induction of neurogenesis, reduction of apoptosis, and promotion of basic fibroblast growth factor (bFGF) expression as possible mechanisms by which treatment of stroke with bone marrow stromal cells (MSCs) improves neurological functional recovery. Additionally, for the first time, we treated cerebral ischemia in female rats with intraveneous administration of MSCs. Female rats were subjected to 2 hr of middle cerebral artery occlusion (MCAo), followed by an injection of 3

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