Cellulose Acetate/Chitosan Multimicrospheres Preparation and Ranitidine Hydrochloride Release In Vitro，成果详细信息-中国科技论文在线

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Cellulose Acetate/Chitosan Multimicrospheres Preparation and Ranitidine Hydrochloride Release In Vitro

陈西广， Hui Yun Zhou ， Xi Guang Chen ， Cheng Sheng Liu ， Xiang Hong Meng ， Chen Guang Liu ， Jun He ， Le Jun Yu

Drug Delivery, 13: 261-267, 2006，-0001，（）：

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摘要/描述

A noval cellulose acetate/chitosan multimicrospheres (CACM) was prepared by the method of w/o/w emulsion. The concentration of cellulose acetate (CA) and the ratio of CA/chitosan (CS) had influence on the CACM size, and appearance. Ranitidine hydrochloride loading, and releasing efficiency in vitro were investigated. The optimal condition for preparation of the microspheres was CA concentration at 2% and the ratio of CA/CS at 3/1. The microspheres size was 200-350 μm. The appearance of microspheres was spherical, porous, and nonaggregated. The highest loading efficiency was 21%. The ranitidine release from the CACM was 40% during 48 hr in buffers.

关键词: Cellulose Acetate, ， Chitosan, ， Controlled Release, ， Multimicrosphere, ， Ranitidine Hydrochloride

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