Sesquiterpene Alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: A New Class of Potent Anti-HIV Agents，成果详细信息-中国科技论文在线

段宏泉

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Sesquiterpene Alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: A New Class of Potent Anti-HIV Agents

段宏泉， Hongquan Duan ， † Yoshihisa Takaishi ， * ， † Yasuhiro Imakura ， ‡ Yongfong Jia ， § Duan Li ， § L. Mark Cosentino ， ⊥and Kuo-Hsiung Lee‖|

J. Nat. Prod. 2000, 63, 357～361，-0001，（）：

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摘要/描述

Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wilfordinines A (3), B (4), and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygium hypoglaucum and a clinically used extract of Tripterygium wilfordii. The structures of 1-5 were elucidated by spectroscopic methods. The anti-HIV activity of 1, 2, and several related compounds was evaluated. Triptonine B (2) demonstrated potent anti-HIV activity with an EC50 value of <0.10

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