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期刊论文
Oridonin-loaded poly(1-caprolactone)-poly(ethylene oxide)-poly(1-caprolactone) copolymer nanoparticles: Preparation, characterization, and antitumor activity on mice with transplanted hepatoma
Journal of Drug Targeting, July 2008; 16(6): 479-485，-0001，（）：
The aim of the present study was to develop a polymeric delivery system for water-insoluble drug oridonin. Amphiphilic block copolymers, poly(1-caprolactone)-poly(ethylene glycol)-poly (1-caprolactone) (PCL-PEO-PCL), were synthesized by ring-opening polymerization of caprolactone initiated by the hydroxyl groups of poly(ethylene glycol)6000 (PEG-6000) with stannous octoate as catalyzer. Oridonin-loaded PCL-PEO-PCL copolymer nanoparticles (ORI-PCL-PEO-PCL-NPs) were prepared by the interfacial deposition method. The mean particle size of the drug-loaded nanoparticles was 97.5nm and the zeta potential was 225mV. The entrapment efficiency and actual drug loading of the nanoparticles were 87.52%
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