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期刊论文
Study on the Gene Transcription Level of Hippocampus NGF in C57 Mouse Development
Journall of Chinese Pharmaceutical Sciences 2009, 9 (2): 108-111，-0001，（）：
D-Nerve growth factor (13 NGF) mRNA levels in hippocampa from CsvBL/6J mice of different ages were compared by semi-quantitative RT-PCR method, taking 13-actin gene as an internal control. The levels of 6-and 12-month-old C57 mice were much lower compared with that of the 1-month-old mouse. However, there was no significant difference between these two groups. This result suggests that gene ranscription level of hippocampus 13 NGF in a C57 mouse descends evidently as it grows up. Base T at Site 294 of 13 NGF cDNA was substituted by C in the C57 mouse, as revealed by DNA sequencing for the first time. Nevertheless, this polymorphism of nucleotide did not make any difference in amino acid composition.
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