Objective To explore whether hypertension can accelerater aging process of the hearing organ, and to understand the relationship between hypertension and aging process. Methods Three-month-old and 12-month-old Wister rats (each group 20), and 3-month-old and 12-month-old SHRSP ratsf (each group 20), with normal tyrnpanic membreane, weighing 200-300g (3-month-old) and 40-600g (12-month-old) (Institute of Cardiovascular Disease, Chinese Academy of Medical Sciences), were selected as two control groups and two experimental groups respectively. The tail artery blood pressure was measured without injury. The threshold of auditory brainstem response (ABR) WAS MEASURED WITH spirit TM evoked potential meter (Nicolet Company)l. The enzyme histochemistry in the inner ear (LDH and ChE) was examined and their optical density were analyzed with HPLAS analytical system. Results It showed no difference in ABR thresholds and activites of LDH and ChE between 3-month-old Wister and SHRSP rats (P>0.05). The mean value of ABR threshold of 12-month-old Wister rats was higher than that of the two 3-month-old groups (P<0.05), LDH and ChE activity of the 12-month-old Wister rats at relevant section were significantly higher and lower respectively than those of the two 3-month-old group (p<0.05), whereas the mean value of ABR threshold of the 12-month-old SHRSP rats and the activities of LDH and ChE at relevant section were significantly higher than those of the wto 3-month-old groups (P<0.01). Conclusions It suggestes that presbycusis exists in 12-month-old Wister rats, and glycogenosis and abnormal secretory of neural transmitter was discerned after hypertension. All above factors may worsen the aging of the hearing system.