Synthesis of cluster mannosides via a Ugi four-component reaction and their inhibition against the binding of yeast mannan to concanavalin A，成果详细信息-中国科技论文在线

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Synthesis of cluster mannosides via a Ugi four-component reaction and their inhibition against the binding of yeast mannan to concanavalin A

管华诗， Yingxia Li ， * Xiaoru Zhang ， Shidong Chu ， Kunyu Yu and Huashi Guan

Carbohydrate Research 339(2004)873-879，-0001，（）：

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摘要/描述

The Ugifour-component reaction (U-4CR) was utilized to prepare divalent and trivalent cluster mannosides with different scaolds. The glycoclusters obtained were tested for their relative inhibitory potency against the binding of yeast mannan to concanavalin A by solid-phase enzyme-linked lectin assays (ELLA) using methyl a-D-mannopyranoside as a standard. Among them, a divalent mannoside containing aromatic groups showed the strongest binding aﬃnity to concanavalin A.

关键词: Ugi four-component reaction ， Cluster mannoside ， Concanavalin A ， ELLA

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