Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-b-chacotriosyl moiety，成果详细信息-中国科技论文在线

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Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-b-chacotriosyl moiety

管华诗， Yichun Zhang ， a Yingxia Li ， a ， * Shilei Zhu ， a Huashi Guan ， a Feng Linb and Biao Yub ， *

Carbohydrate Research 339(2004)1753-1759，-0001，（）：

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摘要/描述

3-O-b-Chacotriosyl-26-O-b-D-glucopyranosyl-(25R)-furost-5-en (1), a mimic of the antitumor active proto-dioscin, was concisely synthesized from diosgenin in a linear nine steps and in 17% overall yield. Its congeners with a a-L-rhamnopyranosyl, blactosyl, or without a substituent at the 26-OH (13-15) were also prepared. Compound 1, as well as 13-15, did not show any inhibition against tumor cells, implying that proto-dioscin might be also inactive, but readily converted into the antitumor active dioscin.

关键词: 3-O-b-Chacotriosyl-26-O-b-D-glucopyranosyl-( ， 25R) ， -furost-5-en ， Proto-dioscin ， Furostan saponin ， Synthesis

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