The galvanic coupling formed in origin-potential flotation systems of sulfide minerals could be divided into three types: sulfide mineral-sulfide mineral-water system; sulfide mineral-steel ball-water system; and sulfide mineral-sulfide mineral-collector system. In this paper, taking lead, zinc, iron sulfide mineral systems as examples, models of galvanic coupling are showed and the effects of galvanic coupling on flotation are discussed. A galvanic contact between galena (or sphalerite) and pyrite benefits to decrease the content of sphalerite in lead concentrates, and can enhance remarkably the absorption of collector on the galena surface. During grinding, due to galvanic interactions between minerals and steel medium, Fe (OH) 3 formed will coat the cathodic mineral surface, affecting its floatability.