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期刊论文

Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells

郭青龙Qing-Long Guo a* Sen-Sen Lin a Qi-Dong You b Hong-Yan Gu a Jun Yu a Li Zhao a Qi Qi a Fei Liang a Zi Tan c Xiaotang Wang c

Q.-L. Guo et al./Life Sciences xx(2005)1~8,-0001,():

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摘要/描述

The activation of human telomerase, a process regulated by the human telomerase reverse transcriptase (hTERT), is a crucial step during cellular immortalization and malignant transformation. We have reported that gambogic acid (GA), a natural product isolated from the gamboges resin of Garcinia hanburyi tree, is an effective telomerase inhibitor and thus displays potent anticancer activity both in vitro and in vivo. Here we present the direct interaction of GA with oncogene c-MYC, a ubiquitous transcription factor involved in the control of cell proliferation and differentiation, as the molecular mechanism of GA's inhibitory effect on telomerase activity. Consistent with the recently reported association between c-MYC overexpression and induction of telomerase activity, we find here that GA treatment of a human hepatoma cell line SMMC-7721 significantly reduced the expression of c-MYC in a time-and concentration-dependent manner accompanied with the down-regulation of the hTERT transcription and the ultimate reduction in telomerase activity. Our results indicate that the hTERT is a target of c-MYC activity and identify a feasible mechanism of GA's potent anticancer activity.

版权说明:以下全部内容由郭青龙上传于   2006年03月03日 17时39分49秒,版权归本人所有。

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