-
69浏览
-
0点赞
-
0收藏
-
0分享
-
222下载
-
0评论
-
引用
期刊论文
Glial Activation and Segmental Upregulation of Interleukin-1β (IL-1b) in the Rat Spinal Cord after Surgical Incision
Neurochem Res (2006) 31: 333-340,-0001,():
The present study investigated the expression patterns of glial cells and interleukin-1b (IL-1b) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain reaction (PCR) and immunohistochemisty showed that IL-1b mRNA and protein level in the spinal cord was transiently upregulated after surgical incision. The increased IL-1b-immunoreactivity (IR) was mainly localized in neurons but not the activated microglia or astrocytes. Although obvious increase in IL-1b-IR could be observed in the lumbar segments of the spinal cord ipsilateral to a hind paw incision, significant upregulation of IL-1b was not detected in the lumbar segments following thoracic incision. The present study indicated that surgical incision could induce glial activation and segmental upregulation of IL-1b in the spinal cord. The activated glial cells and upregulated IL-1b, in turn, may be involved in the incision-induced pain hypersensitivity.
【免责声明】以下全部内容由[郭曲练]上传于[2006年09月29日 23时45分50秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。
本学者其他成果
同领域成果