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期刊论文
Expression of Bone Morphogenetic Proteins and Recentors in Sarcomas
CLINCAL ORTHOPAEDCS AND RELATED RESEARCH Number 365, pp. 175-183,-0001,():
Bone morphogenetic proteins, which are capable of inducing mesenchymal tissue to form bone in mammals, have been implicated as important in normal skeletal developmetl. The expession of bone morphogenentic proteins and their recep-tors were studied In 36 osteosarcoma speelmens, six Ewing' s sarcomas, 20 synuvial sarcomas, and 20 ehondrcomas by reverse transcriptase-polyme rase chain reaction, and the flndings were co.elated with clinical data. Bane morphogene-tic protein-2, and -4 messages were detected in most sarcoma samples. Bone morphogenetic pratein-6 exprssion was detected in 22 of 32 os-teosarcomas and seven of eight chondrco-mas. Bone morphogenetic protein-7 and recep-tar IB were not detected in sarcoma sumples but were detected in three osteosarcoma cell lines and one malignant fibrous histiocytoma cetlline. Expression of bone morphogenetie protein re-ceptor II was found in 25 of 36 ostesarcomas, eight of 20 chondrosarcomas, four of six Ewing' s sarcomas, and 15 of 20 synovial sarcoma sam-pies. Expression of hone morphngenetic protein type 11 receptor was found to currelate with me-tastasis in osteosarcomas, which suggests that the hone morphogenetic protein pathway may participate in tumor aggressivenss or progres-sion. The expression of bone morphogenetic pro-rein receptor 11 in metastatic synovial sarcoma and dedifferentiated chondrosarcoma Iesions also supports this hypathesis. The current study showed that the ligauds fur hone morphogenetic protein receptors, bone morphagenetic proteins-2, -4, and -6 also are expressed in ostecrcoma and other other sarcoma tissues, indicating a potenlial for autocrine or paracrine growth stimulation in these tumors.
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