Large scale mineralizations of nonferrous, precious, and rare metals took place in South China in Mesozoic and Cenozoic Eras, which were mostly closely related with granitic magmatisms of different sources and features. Four metallogenic systems related to Mesozoic and Cenozoic granitoids are put forward in this paper. They are: (i) the porphyry-epithermal copper-gold system related to calc-alkaline volcanic-intrusive magmatism, (ii) rare metal (mainly W, Sn, Ta, Nb, etc) metallogenic system related with continental crust re-melting type granitoids, (iii) copper and polymetallic metallogenic system related with intra-plate high potassium calc-alkaline and shoshonitic magmatism, and (iv) Au-Cu and REE metallogenic system related to A-type granites. The main characteristics of these systems are briefly discussed. These Mesozoic and Cenozoic granitoids of different sources were the products of different periods of lithosphere evolution in that area under different tectonic-dynamic environments. Fundamentally speaking, however, the granitoids and related metallogeneses are the results of mantle-crust interactions under a tensile tectonic environment in South China.