您当前所在位置: 首页 > 学者

胡国宏

  • 7浏览

  • 0点赞

  • 0收藏

  • 0分享

  • 0下载

  • 0评论

  • 引用

期刊论文

New horizons in tumor microenvironment biology: challenges and opportunities

暂无

BMC Medicine volume ,2015,13():45 | 2015年03月05日 | doi.org/10.1186/s12916-015-0278-7

URL:https://link.springer.com/article/10.1186/s12916-015-0278-7#citeas

摘要/描述

The tumor microenvironment (TME) is being increasingly recognized as a key factor in multiple stages of disease progression, particularly local resistance, immune-escaping, and distant metastasis, thereby substantially impacting the future development of frontline interventions in clinical oncology. An appropriate understanding of the TME promotes evaluation and selection of candidate agents to control malignancies at both the primary sites as well as the metastatic settings. This review presents a timely outline of research advances in TME biology and highlights the prospect of targeting the TME as a critical strategy to overcome acquired resistance, prevent metastasis, and improve therapeutic efficacy. As benign cells in TME niches actively modulate response of cancer cells to a broad range of standard chemotherapies and targeted agents, cancer-oriented therapeutics should be combined with TME-targeting treatments to achieve optimal clinical outcomes. Overall, a body of updated information is delivered to summarize recently emerging and rapidly progressing aspects of TME studies, and to provide a significant guideline for prospective development of personalized medicine, with the long term aim of providing a cure for cancer patients.

【免责声明】以下全部内容由[胡国宏]上传于[2020年10月16日 16时48分44秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

我要评论

全部评论 0

本学者其他成果

    同领域成果