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期刊论文

Intestinal absorption of cefbdme in rats1

胡一桥HU Yi-Qiao QIAN Chen-Qing ZHENG Liang-Yuan YU Wei-Hai TAN Ren-Xiang

中国药理学报,1999,20(1):55-58,-0001,():

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摘要/描述

To study the intestinal absorption characters of cefixime (Cef) and the factors affecting Cef absorption. METHODS: A rat intestine loop in situ technique was used to investigate the disappearance rate of Cef from the intestine. Cef concentration in the flux was measured by the reversed phase HPLC. RESULTS: Cef was mainly absorbed from the upper part of the intestine. Its disappearance rate was apparently pH—dependent l(5.8±0.6) nmol•h-1/(g wet tissue)at pH 7.4, (8.9±1.4) nmol•h/(g wet tissue)at pH 5.0, P<0.05) ]. The uptake rate of Cef was curvilinear at 0. 01-0. 5 mmol•L-1. The values of apparent Kt, Jmax, and Kd were 0.114 mmol, 78.41nmol•h-1/(g wet tissue), and 43.70 nmol•h-1•mmol-1/(g wet tissue), respective-ly. Sodium edetate markedly promoted the disappearance rate of Cef from the intestine. CONCLUSION: Cef was transported partly via carrier-mediated transport system and partly via the paracelMar transport system.

版权说明:以下全部内容由胡一桥上传于   2006年08月02日 22时37分55秒,版权归本人所有。

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