In this paper, the quantum phase transition between superfluid state and Mott-insulator state is studied based on an extended Bose-Hubbard model with two-and three-body on-site interactions. By employing the mean-field approximation we find the extension of the insulating 'lobes' and the existence of a fixed point in three dimensional phase space. We investigate the link between experimental parameters and theoretical variables. The possibility to obverse our results through some experimental effects in optically trapped Bose-Einstein Condensates (BEC) is also discussed.