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期刊论文
The Frequency of Occurrence of autoantibodies Against β1-Adrenoceptors and its Clinical Relevance in Patients with Hepatitis Virus Myocarditis
Autoimmunity, Vol. 34, pp. 241-245,-0001,():
The aim of this study was to examine the frequency of occurrence of autoantibodies against β1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correla tion with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=29) and a negative group (Non-HVM group, n=74) according to the laboratory findings regarding their type of hepatilus virus. The study param eters included UCG, ECG, biochemical lindings and screening of autoantibodies against βl-adrenoceptor. It was shown that the positive rate of the hepatitis vies was 28.16% (29/103) in patients with viral myocarditis. The severity of myocardial or liver injunes and the frequency of occurrence of autoantibodies againsl β1-adrenoceptors in patients with viral myocaditis were more pronounced, before treatment, in the HVM group than in the Non HVM group The positive rates of the antibodies against the hepatitis virus and the autoantibodies agzainst β1-adrenoceptors were highly consistent in patients with HVM (p<0.05). In conclusion, the frequency of occurrence of the autoantihodies against β1 -adreno ceptors may be one important marker of HVM and. Thus. possibly involved in the pathogene sis of the HVM.
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