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期刊论文

Breakthroughs and Views Effects of urocortin via ion mechanisms or CRF receptors?

李胜男Jin Tao ab Shengnan Li b*

Biochemical and Biophysical Research Communications 336(2005)731~736,-0001,():

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摘要/描述

Urocortin(UCN),a newly isolated peptide related to hypothalamic corticotrophin releasing factor(CRF)family,had been reported to play biologically diverse roles in several systems such as cardiovascular,reproductive,appetite,stress,and inflammatory responses,etc.It was thought previously to be an endogenous agonist,producing the several actions previously attributed to CRF. But, recently, it was shown to directly reduce L-type calcium currents of acute isolated cardiac myocytes and T-type calcium currents in mouse spermatogenic cells via inhibiting calcium channel instead of binding first to its CRF-R2 receptors.UCN could also reduce the intracellular calcium in vascular smooth muscle cells via inhibiting calcium channel directly.Furthermore,UCN could increase the gene expression of ATP-sensitive potassium channels(KATP)and activate sarcolemmal ATP-sensitive potassium current during normal or hypoxia,which could be inhibited by glibenclamide,a specific KATP blocker.This review will highlight the current novel findings on the ionic mechanisms by which UCN may exert its several actions.

【免责声明】以下全部内容由[李胜男]上传于[2009年08月30日 12时14分31秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

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