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Changes of mu and kappa opioid receptors in cathartic colon of rat
Journal of Medical Colleges of PLA 200419(5):282~284,-0001,():
To observe the changes of mu and kappa opioid receptors in the cathartic colon of rat,and to clarify that whether opioid receptors accounts for the occurrence of slow transit constipation(STC).Methods:The cathartic colon model of rat was made by feeding with laxatives.The activity of mu and kappa opioid receptors in the cathartic colon of rat was measured by radio-ligand binding assay,Results:Compared with the control group,the maximal binding capacity(Bmax)and affinity(Kd)of mu opioid receptor in cathartic colon group were significantly increased(207.00±22.90 fmoL/mg·p vs 82.00±14.23 fmol/mg·p.P<0.01;3.30±0.45 mmol/L vs 2.40±0.57 mmol/L,P<0.05).The maxi-mal binding capacity ofkappa opioid receptor also showed a great increase(957.00±102.41 fmol/mg·p vs 459.00±52.41 fmol/mg·p,P<0.01),but 13o significant diference of afinity was found between the two groups Conclusion:The mu and kappa opioid receptors may be involved in the functional disorders of cathartic colon,
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