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刘刚
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期刊论文
Solution-Phase Synthesis of a 1,5-Dialkylamino-2,4-dinitrobenzene Library and the Identification of Novel Antibacterial Compounds from This Library
J. Comb. Chem. 2000, 2, 467-474 467，-0001，（）：
In this report we demonstrate that a 1,5-dialkylamino-2,4-dinitrobenzene small molecule library can be generated by a highly efficient solution-phase synthesis method. From this 2485-member library, a series of novel compounds with antibacterial activity were isolated. The significance of this report is that the synthetic scheme is extremely simple, with minimal number of liquid handling steps, and the solvents and reagents left in the final library preparation are fully compatible with cell-based assays.
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