The domestic and international E-Business evolution fully proves that the government is playing indispensable function while the country and regional E-Business develop. In the light of the rule of E-Business development and the actual conditions of our country, this paper puts forward a strategy for the government to advance the regional E-Business development, "Focusing the construction on B2B, opening up the virtual trade market; Guiding and developing B2C, following E-Business trend closely; Bringing the two into an organic co-work". For implementing the strategy, the paper proposes a series of out of tactics also in the matter of the government's policy in supporting and enacting E-business in enterprises and other measures.