您当前所在位置: 首页 > 学者

李衍达

  • 66浏览

  • 0点赞

  • 0收藏

  • 0分享

  • 140下载

  • 0评论

  • 引用

期刊论文

Classifying G-protein coupled receptors with bagging classification tree

李衍达Ying Huang* Jun Cai Liang Ji Yanda Li

Computational Biology and Chemistry 28(2004)275-280,-0001,():

URL:

摘要/描述

G-protein coupled receptors (GPCRs) play a key role in different biological processes, such as regulation of growth, death and metabolism of cells. They are major therapeutic targets of numerous prescribed drugs. However, the ligand specificity of many receptors is unknown and there is little structural information available. Bioinformatics may offer one approach to bridge the gap between sequence data and functional knowledge of a receptor. In this paper, we use a bagging classification tree algorithm to predict the type of the receptor based on its amino acid composition. The prediction is performed for GPCR at the sub-family and sub-sub-family level. In a cross-validation test, we achieved an overall predictive accuracy of 91.1% for GPCR sub-family classification, and 82.4% for sub-sub-family classification. These results demonstrate the applicability of this relative simple method and its potential for improving prediction accuracy.

【免责声明】以下全部内容由[李衍达]上传于[2005年08月05日 17时59分08秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

我要评论

全部评论 0

本学者其他成果

    同领域成果