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李元建

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期刊论文

Inhibition of cardiac tumor necrosis factor-a production by calcitonin gene-related peptide-mediated ischemic preconditioning in isolated rat hearts

李元建Jun Peng Jun Xiao Feng Ye Han-Wu Deng Yuan-Jian Li)

European Journal of Pharmacology 407 2000. 303-308,-0001,():

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摘要/描述

Previous investigations have demonstrated that calcitonin gene-related peptideCGRP.plays an important role in the mediation of ischemic preconditioning in rats. In the present study, we examined signal transduction pathways of CGRP-mediated ischemic preconditioning. Thirty minutes of global ischemia and 40 min of reperfusion caused a dramatic decrease in myocardial function, and a significant increase in the release of cardiac creatine kinase in the coronary effluent and in the content of tumor necrosis factor-a TNF-a.in myocardial tissues. However, ischemic preconditioninghree cycles of 5-min ischemia and 5-min reperfusion.or pretreatment with CGRP for 5 min dramatically improved the recovery of cardiac function, and reduced the release of cardiac creatine kinase and the TNF-a content. The effect of ischemic preconditioning was abolished by CGRP-8-37., the selective CGRP receptor antagonist, and by capsaicin, which depletes sensory nerve neurotransmitter content, but was unaltered by treatment with glibenclamide, a blocker of the ATP-sensitive potassiumKATP.channel. The protective effects of exogenous CGRP-induced preconditioning were also not blocked by glibenclamide. These results suggest that the cardioprotective effects afforded by CGRP-mediated ischemic preconditioning are related to inhibition of cardiac TNF-a production, but not to activation of the KATP channel.

【免责声明】以下全部内容由[李元建]上传于[2009年04月03日 15时00分28秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

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