A stage-based quality control scheme, which combines an online adjustment strategy with the authors’ previous works on stage partial least squares(PLS) modeling and quality prediction, is developed for within-batch control of end-product quality for batch processes. Considering the inherent time-specific nature of process trajectories to the end-product quality, a critical-to-quality-control stage is introduced for quality control and stability improvement, together with guidelines on the manipulating variable selection and no-control region. The effectiveness and feasibility of the proposed scheme are illustrated on an injection molding process.