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期刊论文
Detection of methylation of human p16Ink4a gene 5'-CpG islands by electrochemical method coupled with linker-PCR
Nucleic Acids Research, 2003, Vol. 31, No.16 e92，-0001，（）：
Aberrant DNA methylation of the CpG site is among the earliest and most frequent alterations in cancer. Detection of promoter hypermethylation of cancerrelated genes may be useful for cancer diagnosis or the detection of recurrence. p16, an inhibitor of the cyclin D-dependent protein kinases, is a classical tumor suppressor gene, and its inactivation is closely associated with carcinogenesis. p16 hypermethylation could be detected in each stage, which is consistent with the
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