您当前所在位置: 首页 > 学者

马春红

  • 6浏览

  • 0点赞

  • 0收藏

  • 0分享

  • 19下载

  • 0评论

  • 引用

期刊论文

Coinhibitory effect of recombinant tumor necrosis factor α and mutant interleukin-2 on H7402*

马春红Chun-Hong Ma Wen-Sheng Sun Ying-Lin Cao Li-Ning Zhang and Jing Song

Huaren Xiaohua Zazhi, 1998; 6 (2): 97-98,-0001,():

URL:

摘要/描述

AIM To observe the effect of recombinant tumor necrosis factor α (rHTNFα) and mutant interleukin 2(IL-2) on the hepatocarcinoma cell line in vitro. METHODS The hepatocarcinoma cell line (H7402) was used as a cell culture system in vitro. H7402 was cultured with different concentrations of rHTNFα and/or mutatant IL-2. The cytotoxity was measured by short term MTT method. RESULTS The inhibitory effect on H7402 became stronger with the increase of the concentration of rHTNFα (r=0.909,P<0.05). Mutatant IL-2 had no direct inhibitory effect, but could enhance the effect of rHTNF α in inhibiting H7402 cell line. The concentration of both rHTNF α and mutant IL-2 affected this enhancement: 2.5×10.3U/ml of mutant IL-2 could increase cytotxity of rHTNFα (1000 U/ml) to H7402 effectively. When rHTNFαreached 5×10 4U/ml, the enhancement appeared only when the concentration of mutant IL-2 was at 2×10 4U/ml. If the dose of rHTNFαwas at 8×104 U/ml, the inhibitory effect did not rise significantly until mutant IL-2 was at 4×10 4U/ml. CONCLUSION rHTNFα combined with mutatant IL-2 in low concentration can yield good inhibitory effect on hepatocarcinoma.

【免责声明】以下全部内容由[马春红]上传于[2009年03月18日 15时15分25秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

我要评论

全部评论 0

本学者其他成果

    同领域成果