您当前所在位置: 首页 > 学者

仇缀百

  • 12浏览

  • 0点赞

  • 0收藏

  • 0分享

  • 297下载

  • 0评论

  • 引用

期刊论文

Synthesis and relative bioavailability of meptazinol benzoyl esters as prodrugs

仇缀百Meiyan Lu Chengji Zhang Jinglai Hao and Zhuibai Qiu*

Bioorg. Med. Chem. Lett. 15(2005)2607-2609,-0001,():

URL:

摘要/描述

Three meptazinol benzoyl esters (1-3) were synthesized as prodrugs to minimize the first-pass effect of meptazinol and improve the bioavailability. Among these three esters, compound 3 showed better bioavailability than the parent meptazinol. Further, the relative regional bioavailability of prodrug 3 was evaluated using in situ closed loop study in rats, which showed that prodrug 3 has higher absorption efficacy in rat intestine. Thusly, prodrug 3 may be worth for further development.

关键词:

版权说明:以下全部内容由仇缀百上传于   2006年07月06日 19时15分17秒,版权归本人所有。

我要评论

全部评论 0

本学者其他成果

    同领域成果