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1-甲基-3-乙基-3-(3羟基苯基)-六氢-1H-氮杂-卓盐酸盐的合成*

仇缀百郝敬来李炜谢琼陈燕仇缀百△

复旦学报(医学版)2005,32(2):173~177,-0001,():

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摘要/描述

Purpose To prepare 1-metyh1-3-ethy1-3(3-hydroxyhenyl)-hexahydro-1 H-azepin hy-drochloride (I) from m-methoxyacetophenone. Methods 1-methy1-3-(3-hydrox yphenyl)-hex-ahydro-1 H-azepin hydrochloride (I) was synthesized by eight steeps with m-methoxyacetophenone as start-ing material. The eight steps were willgerodt rearrangement, formation of acyl chloride, acylride and salt for-mation. Results 1-methy1-3-ethy1-3(3-hydroxypheny1)-hexahydro-1 H-azepin Hydrochlorde (I) was prepared in eight steps from cheap material and reagent on normal condition. Conclusions This method is applicable to industrial production.

版权说明:以下全部内容由仇缀百上传于   2006年07月06日 19时12分13秒,版权归本人所有。

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