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期刊论文

Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol

仇缀百Qiong Xie Xiaolin Wang Xinghai Wang Zhiqiang Jiang and Zhuibai Qiu*

Bioorg. Med. Chem. Lett. 15(2005)4953-4956,-0001,():

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摘要/描述

Based on the known coumarin-based prodrug system, a new meptazinol (Z)-3-[2-(propionyloxy) phenyl]-2-propenoic ester (3) was designed and synthesized as prodrug to minimize the first-pass effect of meptazinol (1) and improve the oral bioavailability. The prodrug (3) showed a 4-fold increase in oral bioavailability over the parent drug meptazinol in rats.

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版权说明:以下全部内容由仇缀百上传于   2006年07月06日 19时13分59秒,版权归本人所有。

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