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曲显俊

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Caffeoyl Pyrrolidine Derivative LY52 Inhibits Tumor Invasion and Metastasis via Suppression of Matrix Metalloproteinase Activity

曲显俊XIANJUN QU YUNXIA YUAN WENFANG XU MINGHUI CHEN SHUXIANG CUI HONG MENG YAN LI MASATOSHI MAKUUCHI MUNEHIRO NAKATA and WEI TANG

ANTICANCER RESEARCH 26: 3573-3578(2006),-0001,():

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摘要/描述

Abstract. Background: LY52 is a caffeoyl pyrrolidine derivative designed to fit and extend into the active pocket of matrix metalloproteinase (MMP). In this study, the effects of LY52 on MMP-2 and MMP-9 activities and tumor invasion and metastasis were examined. Materials and Methods: MMP expression in SKOV3 cells was analyzed by gelatin zymography. The anti-invasion and anti-metastasis abilities of LY52 were evaluated with penetration of SKOV3 cells through Matrigelcoated membrane in vitro and pulmonary metastasis of Lewis lung carcinoma in mice, respectively. Results: LY52 significantly blocked the proteolytic activity of gelatinase. Gelatin zymography revealed that MMP-2 and MMP-9 expressions in SKOV3 cells were reduced in the presence of LY52. LY52 also suppressed SKOV3 cell invasion in vitro. Furthermore, a significant inhibition of pulmonary metastasis of Lewis lung carcinoma cells was observed in LY52-administrated mice. Conclusion: LY52 might suppress invasion and metastasis of carcinoma cells via inhibition of MMP-2 and MMP-9 proteolytic activities.

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