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期刊论文
SO2 inhalation inducesproteinoxidation,DNA-proteincrosslinksand apoptosisinrathippocampus
Ecotoxicology and Environmental Safety 72(2009)879-884，-0001，（）：
Previous studiesprovideevidenceforthepossibleneurotoxicityof SO2, butlittleinformationis availableaboutitsmechanisms. Inthepresentstudy, SO2 inhalation-inducedeffectsontheprotein oxidation, DNA-proteincrosslinksandapoptosisinrathippocampuswerestudied, byexposingWistar rats to SO2 at 14, 28and56mg/m3. Theresultsindicatethattheproteincarbonylcontent, anindicatorof proteinoxidation, andDNA–proteincrosslinkcoefficientweresignificantlyaugmented with concentration-dependentproperties. Inaddition, SO2 inhalationatallconcentrationstestedcaused the increasesofcaspase-3activityandnumberofTUNELpositivestainingneuronandthestatistical difference asobservedafter28and56mg/m3 exposure, suggestingtheoccurrenceofapoptosis. The results implythatattackingprotein, nucleicacidsandlipidsbyfreeradicals, generatedvia SO2 derivatives in vivo, isoneofthemainmechanismsfor SO2-inducedinjuriesincentralneuronalsystem
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