A new and comtinuous process has been designed to determine the solubility of Daqing-Huangdao vacuum residue (DHVR) in rnixing C4 solvent. The solubility parameters of DHVR have been calculated using the Flory-Huggins equation under a ternperature range of 405-415K. The solubility parameter of DHVR at 25℃ obtained by the extrapolation method is coincident with literature values reported. The solvent solubility parameter and the influence of temperature have also been studied and a simple and satisfactory equation has been built. The influnce of solvent composition on solubility of DHVR has also been diseussed in this paper and some rnethods to inrease the slouility of DHVR in mixing C4 solvent have been inroducde.