This paper focuses on the theoretical basis for the study of wave scattering from an interface crack in multilayered piezoelectric media. The materials are taken to be anisotropic with arbitrary symmetry. Based on the Fourier transform technique together with the aid of the stiffness matrix approach, the boundary value problem of wave scattering is reduced to solving a system of Cauchy-type singular equations. The intensity factors and crack opening displacements are defined in terms of the solutions of the corresponding integral equations for any incident frequencies and incident angles. Numerical results are presented. The effects of incident frequencies and crack location on both the major and coupling intensity factors are illustrated. The influence of the piezoelectricity is also shown.