Interfacial fatigue of reinforced concrete under tension fatigue loading is simulated based on the shear-lag model. The effects of degradation of concrete strength, the loading frequency and the stress ratio as well as corrosive environment on the interfacial fatigue are considered and discussed. It is found that: (1) degradation of concrete strength and corrosive environment result in opposite effects on interfacial fatigue. (2) Degradation of concrete strength will result in larger effects on interfacial damage in low stress ratio than that in high stress ratio. (3)With a decrease of loading frequency, interfacial corrosion damage will remarkably increase though loading frequency has a small effect on fatigue crack growth in inert media.