Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility，成果详细信息-中国科技论文在线

宋后燕

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Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility

宋后燕， Yue-Xiang Wang a ， Lin-Xi Qian a ， Zhang Yu c ， Qiu Jiang a ， Yong-Xin Dong a ， Xue-Fei Liu a ， Xin-Ying Yang a ， Tao P. Zhong a ， b ， * ， Hou-Yan Song a

FEBS Letters 579(2005)4843-4850，-0001，（）：

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摘要/描述

Myocyte-specific enhancer factor 2A (MEF2A) regulates a broad range of fundamental cellular processes including cell division, differentiation and death. Here, we tested the hypothesis that MEF2A is required in cardiac contractility employing zebrafish as a model organism. MEF2A is highly expressed in heart as well as somites during zebrafish embryogenesis. Knock-down of MEF2A in zebrafish impaires the cardiac contractility and results in sarcomere assembly defects. Dysregulation of cardiac genes in MEF2A morphants suggests that sarcomere assembly disturbances account for the cardiac contractile deficiency. Our studies suggested that MEF2A is essential in cardiac contractility.

关键词: MEF2A ， Cardiac contractility ， Zebrafish ， Development ， Morpholino ， Morphant

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