提示
宋怀东
-
60浏览
-
0点赞
-
0收藏
-
0分享
-
39下载
-
0评论
-
引用
期刊论文
Molecular Evolution of the SARS Coronavirus During the Course of the SARS Epidemic in China
12 MARCH 2004 VOL 303 SCIENCE，-0001，（）：
Sixty-one SARS coronavirus genomic sequences derived from the early, middle, and late phases of the severe acute respiratory syndrome (SARS) epidemic were analyzed together with two viral sequences from palm civets. Genotypes characteristic of each phase were discovered, and the earliest genotypes were similar to the animal SARS-like coronaviruses. Major deletions were observed in the Orf8 region of the genome, both at the start and the end of the epidemic. The neutral mutation rate of the viral genome was constant but the amino acid substitution rate of the coding sequences slowed during the course of the epidemic. The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization.
【免责声明】以下全部内容由[宋怀东]上传于[2007年09月14日 15时34分07秒]，版权归原创者所有。本文仅代表作者本人观点，与本网站无关。本网站对文中陈述、观点判断保持中立，不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考，并请自行承担全部责任。
本学者其他成果
同领域成果
